The best weed strains vary patient-to-patient. When comparing indica vs. sativa, some medical cannabis consumers prefer the sedative effects of an indica, and others need a sativa for daytime use. Below are seven top indica dominant cannabis strains.

OG kush

This classic indica dominant marijuana strain originates from Southern California. It averages 19% to 20% THC that hits hard and fast. The 75%/25% indica flowers also contain about 1% CBN. It produces a lemon flavor with a woodsy aftertaste and a robust pine aroma that has earthy undertones. The light green buds are covered in a thick layer of rust-colored pistils and a fine coating of crystal clear trichomes.

Expect a couch-lock with this nighttime strain. OG Kush can take down the most experienced users with the one-two combo of THC and CBN. The sativa gives the classic Kush a cerebral boost that can keep ADHD patients focused in small doses. Users also report it’s excellent for dissolving chronic pain, calming hyperactivity, and giving patients a much-needed mood boost to kick away depression. Additionally, OG Kush may help with migraines and headaches.

Indica strain OG kush

Blue Dream

Blue Dream is a popular hybrid that’s almost a 50/50 Indica-Sativa. The popular strain is well-loved on both coasts. It has between 17% and 24% THC, 2% CBD, and 1% CBN. It’s a cross between Blueberry and Haze. The potent flowers have a fruity, blueberry flavor with sweet vanilla undertones and an earthy aroma with vanilla undertones. It has large dense, round fluffy buds that are bright green with amber pistils.

The uplifting flower is energizing, but the indica keeps it from going over the top. It’s ideal for ADD/ADHD and keeping your brain in check during the day. The CBD and CBN help reduce anxiety, and many PTSD patients use Blue Dream to unwind and sleep better at night.

Blue Dream

Girl Scout Cookies

Girl Scout Cookies, also known as GSC, is a 60%/40% indica dominant cannabis strain that’s a cross between OG Kush and F1 Durban Poison. It has a yummy cherry-lemon flavor with minty undertones and a sweet, vanilla-nut aroma. The High Times Cannabis Cup winner has Christmas tree-shaped buds that are light green, fluffy, and sparsely covered in bright orange pistils. 

The potent hybrid averages 25% THC,1% CBD, and 1% CBN. The CBD and CBN put it over as an appeasing nighttime bud. It’s best to avoid GSC during the day if you have tasks to accomplish. The couch-lock is real with the delicious flowers. Patients with chronic pain report relief, and the tranquilizing-effect is ideal for putting them to sleep at night.

Weed Strain Girl Scout Cookies

Wedding Cake

Skip the visions of a heavily frosted white wedding cake. The indica dominant hybrid is a cross between Cherry Pie and the very famous Girl Scout Cookies. It has a fruity flavor and a sweet berry aroma that’s as delicious as it is effective. The tightly packed pine tree-shaped flowers are light green with dark green leaves, orange pistils, and a thick layer of powdery white trichomes. 

The 25% THC is ideal for chronic pain. Wedding Cake is a clear nighttime bud that’s great for unwinding with before bed for patients with sleep disorders, such as insomnia. The potent flowers are the top choices for patients with fibromyalgia for muscle pain relief. Wedding Cake also helps people with MS reduce muscle spams. It works for all patients to reduce the depression and anxiety that often accompanies their conditions.

Purple Punch

Purple Punch Strain is an indica dominant hybrid that’s 80%/20%. The popular flowers contain between 18% and 20% THC and 1% CBD, offering more of the non-psychoactive cannabinoid than other high-THC flowers. It produces a sweet flavor that blends blueberry, grape, candy, and vanilla. The scent is as delicious as the flavor, with sweet blueberries and an earthy undertone. Some patients claim it tastes like sour grape candy. Purple Punch has bright green, fluffy large flowers with a few red-orange pistils spread throughout it. 

The potent flowers knock pain away fast, leaving you with an invigorating euphoria that lifts your mood and pushes away stress. Don’t sway far from the kitchen. You can’t escape the munchies with Purple Punch. The appetite boost makes it perfect for patients with nausea. The after-dark strain is ideal for anyone with sleep issues. A few puffs of Purple Punch before bed can put most users out for the night.

Purple Punch Strain


G-13 is a legendary strain that’s been helping boost moods since the 1970s. Also known as Government Indica Strain 1, it’s a 70%/30% indica dominant flower. Its parentage is mostly unknown. Growers know the popular hybrid began as a pure Afghani indica strain developed over the past 40 years. It has an old-school earthy aroma that’s pungent with berry undertones and a sweet flavor with a woodsy aftertaste. The buds are dark, dense, and olive green with a light coating of amber pistils and a thick layer of frosty trichomes.

Patients are using the medical strain for many reasons, with most people choosing it to boost mood, fight depression, and send anxiety packing. G-13 is also excellent for people with chronic pain, such as arthritis and regular migraines. Consumers report the potent flowers to help push away stress and PTSD symptoms.

G-13 Cannabis Strain


Blueberry is a yummy 80%/20% indica dominant marijuana strain with 16 to 24% THC. Cannabis cultivars have been perfecting the variety since the 1970s. It has a delicious sweet blueberry taste with woodsy undertones. 

The grape-shaped flowers are olive green with brilliant dark blue tones and fiery orange pistils. A close look reveals a thick, frosty coating of amber trichomes.

Blueberry is a High Times’ Cannabis Cup-winning indica strain that’s ideal for unwinding. Consumers report a fast mood boost, driving away depression and anxiety. Other conditions patients use Blueberry for include ADHD, insomnia, nausea, and migraines.

Blueberry Indica Strains


Originally known as Gorilla Glue #4, GG#4 is a legendary cannabis strain close to a 50/50 indica/sativa hybrid. Gorilla Glue is a cross of Chem’s Sister, Sour Dubb, and Chocolate Diesel. The bright green buds with tiny twists of orange hairs and a thick layer of powdery trichomes will also zap away pain and help you stay focused all day long.

HITit offers an indoor-cultivated GG#4 that keeps you going during the day with its sativa qualities. Add GG#4 to your all-green medicine cabinet today and say goodbye to chronic pain, muscle spasms, and stress. Toke GG#4 slowly, the heavy THC content can overpower the most experienced recreational cannabis users.

GG#4 Weed Strains


Gelato is an indica dominant hybrid that’s a cross of Sunset Sherbet and Thin Mint Girl Scout Cookies. It averages 20% THC and has a blueberry and orange sherbet flavor with a citrus berry aroma and lavender undertones. Gelato has dark, forest green flowers with deep purple shades throughout and a thick layer of orange pistils. The buds are coated in a sticky layer of clear trichomes.

It produces a head high that sends chronic pain, headaches, and muscle spasms far away. The sativa qualities of the bud keep the couch-lock at bay. However, heavy hits will still produce a blissful sleep for patients with insomnia.

Gelato cannabis strain

Indica vs. Sativa: What are the Differences?

Indica vs. sativa is more about potential effects than exact formulas. Each cannabis plant gets its unique characteristics from the blend of cannabinoids, terpenes, and flavonoids in each strain. But indica and sativa still offer general qualities. 

Indica strains are often more mellowing than sativas. Consumers frequently prefer using these flowers in the evening to prevent downtime during the day. An indica is excellent for pain relief and insomnia. 

Sativas, on the other hand, are known to be more energizing, support creativity, and provide an uplifting effect. Additionally, the sativa is much less sedative than an indica. These are also great for pain but also offer a more cerebral response.

Cannabis Cannabinoids

Cannabis is an amazing plant. Most consumers are aware of THC and CBD, but the potent plant has at least 545 naturally occurring compounds. Nature’s formula consists of over 140 phytocannabinoids, up to 200 known terpenes, and more than a dozen flavonoids. The two dominant primary cannabinoids are THC and CBD.


THC, also known as tetrahydrocannabinol, is one of three delta THC compounds. Most consumers know about delta-9 THC. It bonds at the 9th carbon and is known for a robust psychoactive response. The cannabis plant has two other delta compounds, delta-8 THC and delta-10 THC. These are making rounds with patients that don’t like how potent delta-9 THC is but feel CBD isn’t strong enough. Some consumers are calling delta-8 and delta-10 THC “THC-lite.” Delta 10 is a slight bit more potent than delta 8. THC binds directly to the cannabinoid receptors in the body, explaining why the reaction to the cannabinoid is stronger than CBD.


CBD, also known as cannabidiol, is a non-psychoactive compound. It has the same chemical structure as THC, but the order is slightly different. CBD interacts with the cannabinoid receptors like THC, but it doesn’t physically attach to the CB1 or CB2. 

Experts believe this slight difference explains why the cannabinoid doesn’t produce a high but still provides plenty of benefits. Until the past few years, CBD percentages in cannabis strains have stayed low, most under 1%. Recently, breeders have been increasing the amount of CBD in cannabis varieties to reach more patients. CBD offers pain relief, reduces inflammation, relieves anxiety, and improves sleep.

Medical Efficacy of Cannabis Cannabinoids

Hundreds of studies are available supporting the science behind cannabinoids’ medical Efficacy. Cannabis research pre-dates modern times. For example, there’s evidence supporting cannabinoids for pain over 150 years. Dr. W.B. O’Shaughnessy was a cannabis pioneer, documenting its use for pain in medical journals starting in the 1840s. 

In the modern era, research has been ongoing since the 1940s, when the first cannabinoid was isolated in cannabis. In the 1990s, scientists had the most advances. They verified the endocannabinoid system, or ECS, is a cell-signaling system in all mammals’ bodies. 

The system explains why cannabinoids have such a broad reach for treating symptoms and diseases. It regulates pain, appetite, hormones, blood sugar, immune function, the sleep cycle, reproduction, and many other natural processes in the body. 

The researchers also concluded people didn’t need to consume cannabis products to activate the ECS. Your body has this entire process down to a science and keeps it running smoothly. Additionally, they’ve learned how cannabinoids can improve the balance when there’s a deficiency.

Although more clinical studies are necessary, scientists have preliminary evidence that medical cannabis can help with a wide range of conditions and symptoms, including:

  • Side effects of chemotherapy
  • Wasting disease associated with HIV/AIDS
  • IBD
  • IBS
  • Chronic pain
  • Spasticity associated with multiple sclerosis
  • PTSD
  • Mood disorders
  • Seizure disorders
  • Degenerative neurological conditions
  • ALS
  • Huntington’s disease
  • Parkinson’s disease
  • ADHD
  • Sleep disorders
  • Anxiety
  • Stress

Although this list isn’t exhaustive, it provides an example of how many ailments medical cannabis has the potential to treat. As more research is available for individual cannabinoids and their potential, we’ll better understand the full range of benefits cannabis offers.

How to choose the best cannabis strain for your needs

Picking the right indica or sativa cultivar depends on your ailments, severity, experience level, and overall preference. Indica vs. sativa is more of a guideline. It may require trial and error with different hybrids to find your sweet spot. 

Also, although cannabis isn’t addicting or habit-forming, your body can get used to the all-natural medicine. Tolerance with cannabis isn’t a huge problem. But it means it will take more to get the same result. Patients can improve efficiency by switching between different strains. 

The general rule is you choose an indica for nighttime use. These produce a more heady high that sends stress away and induces sleep. Many patients choose indica for insomnia and other sleep disorders. Keep an indica in your medicine cabinet to help unwind at the end of the day and make you sleepy at night. Yes, these will take away your pain, but they won’t keep you energized and up all night like the sativa might.

Sativas are considered daytime flowers that won’t produce the couch-lock you can experience with an indica. These strains may improve focus while eliminating pain and nausea. Additionally, many patients pick a sativa for mood disorders. The invigorating cultivars boost mood while helping with the side effects of conditions like depression by adding a smile to your face, zapping away stress, and improving appetite.

Reasons to use a hybrid

You can also get the best of both worlds with a 50/50 hybrid. These will make you a little tired, but not to the extremes of an indica dominant flower. At the same time, the cannabis types will allow enough focus to watch a movie without falling asleep halfway through it. 

Keep in mind that most hybrids aren’t 50/50 but varying blends, such as 25/75, 30/70, and 55/45. To learn more about how the different hybrids can help you, look at the natural formula’s various minor cannabinoids and terpenes. 

Not sure which to choose? HITit offers the best weed strains. We have indica dominant, sativa-dominant, and 50/50 hybrids to take care of any ailment, from chronic pain and nausea to mood disorders and insomnia. Buy safe, top-shelf medical marijuana from HITit. Our flowers are cultivated indoors and handpicked to preserve every cannabinoid and terpene carefully.